Andrei Barborica, VP of FHC Europe and CTO of FHC, Inc., has coauthored two studies that have been accepted for publication by Clinical Neurophysiology.  In both studies, FHC’s Guideline 4000 LP+ was used as the programmable stimulator to apply complex waveforms through intracranial electrodes, allowing researchers to analyze the responses to the intracranial stimulation in various ways.

In “High frequency spectral changes induced by single-pulse electric stimulation: comparison between physiologic and pathologic networks,” researchers determined that physiologic and pathologic interactions can be assessed using spectral changes induced by SPES, finding a promising method for connectivity studies in patients with drug-resistant focal epilepsy.  More information on this paper is available at http://dx.doi.org/10.1016/j.clinph.2016.12.016.

In the second study, titled “Co-occurrence of high-frequency oscillations and delayed responses evoked by intracranial electrical stimulation in stereo-EEG studies,” researchers conducted the first direct comparison of high-frequency oscillations and delayed responses using stereo-EEG.  FHC’s WayPoint Navigator was used to determine electrode positioning and Guideline 4000 LP+ was used as the programmable stimulator to apply complex waveforms through these intracranial electrodes.  The authors concluded there is a moderate similarity in the information provided by the DRs and HFOs.  More information on this paper is available at http://www.clinph-journal.com/article/S1388-2457(16)31008-2/fulltext.